-
Target antigen
FGG
-
Clonality
Polyclonal antibody
-
Clone
Polyclonal antibody
-
Raised in
rabbit
-
Type of the antibody
IgG polyclonal antibody
-
Product form
freeze-dried
-
Reacts with species
mouse
-
Analyses
WB,IHC-P
-
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FGG (133-163aa IRYLQEIYNSNNQKIVNLKEKVAQLEAQCQE), different from the related mouse sequence by two amino acids, and from the related rat sequence by five amino acids.
-
Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
-
Purification
Immunogen affinity purified.
-
Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
-
Storage condtions
Keep the FGG Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
-
Tips
The FGG Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
-
Background
Fibrinogen gamma chain, also known as FGG, is a human gene found on Chromosome 4. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.
-
Related articles
1. Budzynski, A. Z., Marder, V. J., Menache, D., Guillin, M.-C. Defect in the gamma polypeptide chain of a congenital abnormal fibrinogen (Paris I). Nature 252: 66-68, 1974. 2. Ebert, R. F., Bell, W. R. Fibrinogen Baltimore III: congenital dysfibrinogenemia with a shortened gamma-subunit. Thromb. Res. 51: 251-258, 1988. 3. Fornace, A. J., Jr., Cummings, D. E., Comeau, C. M., Kant, J. A., Crabtree, G. R. Structure of the human gamma-fibrinogen gene: alternate mRNA splicing near the 3-prime end of the gene produces gamma-A and gamma-B forms of gamma-fibrinogen. J. Biol. Chem. 259: 12826-12830, 1984.
-
Gene Name
FGG
-
Protein Name
Fibrinogen gamma chain
-
Gene Full Name
fibrinogen gamma chain
-
Synonyms
FGG | Fibrinogen gamma chain | Fibrinogen gamma polypeptide | fibrinogen gamma-b chain | P02679
-
Uniprot ID
P02679
-
Entrez GeneID
2266
-
Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
