Panobinostat (LBH589)
-
Catalog number1612-1
-
PricePlease ask
-
Size1 mg
-
-
Alternative_nameLBH589, LBN-589,NVP-LBH589
-
DescriptionPanobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC₅₀ values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC₅₀ value is 4.6±1.8 nM.
-
CAS Number404950-80-7
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₁H₂₃N₃O₂
-
Molecular Weight349.43
-
Cell PermeableYes
-
Purity≥99% by HPLC
-
SolubilitiesDMSO
-
HandlingProtect from air and moisture
-
Tag LineA HDAC inhibitor
-
Storage Condition-20°C
-
Shipping ConditionRT
-
Shelf Life24months
-
MDL NumberMFCD09833242
-
PubChem CID6918837
-
SMILESCC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
-
InChiInChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6- 16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24, 25)/b11-10+
-
InChi KeyFPOHNWQLNRZRFC-ZHACJKMWSA-N
-
MSDS AvailableYes
-
Gene target
-
Short namePanobinostat (LBH589)
-
Alternative namePanobinostat (LBH589)
-