Panobinostat (LBH589)

• Catalog number
  1612-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  LBH589, LBN-589,NVP-LBH589
• Description
  Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC₅₀ values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC₅₀ value is 4.6±1.8 nM.
• CAS Number
  404950-80-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₃N₃O₂
• Molecular Weight
  349.43
• Cell Permeable
  Yes
• Purity
  ≥99% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and moisture
• Tag Line
  A HDAC inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  RT
• Shelf Life
  24months
• MDL Number
  MFCD09833242
• PubChem CID
  6918837
• PubChem CID Link
• SMILES
  CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
• InChi
  InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6- 16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24, 25)/b11-10+
• InChi Key
  FPOHNWQLNRZRFC-ZHACJKMWSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Panobinostat   LBH589  
• Short name
  Panobinostat (LBH589)
• Alternative name
  Panobinostat (LBH589)

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