anti-GEMC1 Antibody

• Catalog number
  6385
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  GEMC1 Antibody: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
• Gene names
  GEMC1 Antibody: GEMC1, GEMC1, Geminin coiled-coil domain-containing protein 1
• Antibodie s label
  unlabelled serum
• Purity
  GEMC1 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  GEMC1 antibody was made against a 19 amino acid synthetic peptide near the center of human GEMC1.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  GEMC1 antibody can be used for detection of GEMC1 by Western blot at 1 ug/mL.
• Suspention pH azide
  GEMC1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  GEMC1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse
• Omim nr
  226442751
• Ncbi nr
  NP_001140158
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  647309
• GENE symbol
  GEMC1
• Antigene name
  geminin coiled-coil domain-containing protein 1
• Source
  Homo sapiens
• Protein nr
  A6NCL1
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  GEMC1  
• Gene symbol
  GMNC
• Short name
  anti-GEMC1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toGEMC1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40049
• Gene
  GMNC
• Long gene name
  geminin coiled-coil domain containing
• Synonyms
  • GEMC1
• GenBank acession
  • BC031680
• Locus
  3q28
• Discovery year
  2011-08-19
• Entrez gene record
  647309
• Pubmed identfication
  • 20383140
  • 20855966
• RefSeq identity
  • NM_001146686
• VEGA ID
  OTTHUMG00000156195

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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