Smo Agonist, SAG

Alternative_name

N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane
Description

Cell-permeable. A Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.
CAS Number

912545-86-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₈H₂₈ClN₃OS
Molecular Weight

490.06
Cell Permeable

Yes
Purity

≥98% by NMR
Solubilities

DMSO (>40 mg/ml)
Handling

Protect from light
Tag Line

A Smoothened (Smo) agonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
SMILES

N/A
InChi

N/A
InChi Key

N/A
Data Sheet Link
MSDS Available

Yes

Gene target

Smo Agonist SAG
Gene symbol

SAG, RNF7
Short name

Smo Agonist, SAG
Alternative name

smoothened, frizzled family receptor Agonist, SAG
Alternative to gene target

smoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308

Identity

HGNC:10070
Gene

RNF7
Long gene name

ring finger protein 7
Synonyms
- SAG
- ROC2
- CKBBP1
Synonyms name
- sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
GenBank acession
- AF092878
Locus

3q23
Discovery year

1999-05-28
Entrez gene record

9616
Pubmed identfication
- 10082581
- 10230407
RefSeq identity
- NM_014245
Classification
- Ring finger proteins
VEGA ID

OTTHUMG00000141305