ML-323

Alternative_name

4-Pyrimidinamine, 5-methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-
Description

ML323 is a potent, reversible, inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
CAS Number

1572414-83-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₄N₆
Molecular Weight

384.48
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>50 mg/ml) or EtOH (>25 mg/ml)
Handling

Protect from air and light
Tag Line

A USP1-UAF1 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

60167849
PubChem CID Link
SMILES

CC1=CN=C(N=C1NCC2=CC=C(C=C2)N3C=CN=N3)C4=CC=CC=C4C(C)C
InChi

nChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
InChi Key

VUIRVWPJNKZOSS-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes