AAK1 Polyclonal Antibody

  • Catalog number
    CAC07794
  • Price
    Please ask
  • Size
    100 μg
  • Other name
    AP2-associated protein kinase 1,Adaptor-associated kinase 1,AAK1,KIAA1048
  • Immunogen
    Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
  • Verified reactivity
    Human, Mouse
  • Verified applications
    ELISA,WB,IHC,IF. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200,IF:1:50-1:200
  • Raised in
    Rabbit
  • Clonality
    Polyclonal
  • Protein number
    Q2M2I8
  • Gene number
    Please refer to GenBank
  • NCBI number
    Please refer to NCBI
  • Purity
    Protein G purified, >95%
  • Storage recommendation
    Aliquot and store at -20°C. Minimize freezing and thawing.
  • Use before
    1 year
  • Shipping requirements
    Blue ice
  • Estimated production time
    3-7 business days
  • Supplementary information
    Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
  • Notes
    For research use only. Not for diagnostic procedures.
  • Properties
    If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Group
    Polyclonals and antibodies
  • About
    Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
  • French translation
    anticorps
  • Gene target
    AAK1  
  • Gene symbol
    AAK1
  • Short name
    AAK1 Polyclonal Antibody
  • Technique
    Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
  • Label
    Unconjugated
  • Alternative name
    AAK1 polyclonal (antibody to-)
  • Alternative technique
    polyclonals, antibodies
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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