Rottlerin

• Catalog number
  1827-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone; Mallotoxin
• Description
  Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However, more recent studies have shown Rottlerin did not block PKCδ activity but did block other kinase and non-kinase proteins in vitro and activated multiple Ca²⁺-sensitive K⁺ channels with high potency. It uncouples mitochondria and affects mitochondrial production of reactive oxygen species (ROS). Also induces autophagy through inhibition of mTORC1.
• CAS Number
  82-08-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₂₈O₈
• Molecular Weight
  516.55
• Cell Permeable
  No
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (30 mg/ml) or Ethanol (1 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An autophagy inducer
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00017361
• PubChem CID
  5281847
• PubChem CID Link
• SMILES
  CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)C=CC4=CC=CC=C4)OC(C=C3)(C)C)O)O
• InChi
  InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
• InChi Key
  DEZFNHCVIZBHBI-ZHACJKMWSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Rottlerin  
• Short name
  Rottlerin
• Alternative name
  Rottlerin

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