Myostatin, human recombinant

• Catalog number
  4623-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy
• Alternative_names
  GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy
• Description
  A secreted growth differentiation factor
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  Determined by its ability to inhibit the proliferation of MPC-11 cells. The ED₅₀ for this effect is
• Molecular Weight
  24.8 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and lyophilized with no additives
• Reconstitution Instructions
  It is recommended to reconstitute the lyophilized human Myostatin in sterile 20 mM acetic acid to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers.
• Background Information
  Myostatin, also known as Growth Differentiation Factor-8 (GDF-8), belongs to the TGF-β superfamily. Along with other members of the TGF-β family, Myostatin plays a crucial role as a regulator for embryonic development and tissue homeostasis in adult animals. Early studies show that Myostatin has the ability to halt muscle growth. New research has further suggested that Myostatin may also be involved in reducing and preventing adiposity and type-2 diabetes. Human Myostatin is a homodimeric protein with each subunit containing 109 amino acid residues with a total molecular weight of 24.8 kDa.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Myostatin  
• Gene symbol
  MSTN
• Short name
  Myostatin, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Myostatin, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:4223
• Gene
  MSTN
• Long gene name
  myostatin
• Synonyms gene
  • GDF8
• Synonyms gene name
  • growth differentiation factor 8
• GenBank acession
  • AF019627
• Locus
  2q32.2
• Discovery year
  1997-09-12
• Entrez gene record
  2660
• Pubmed identfication
  • 9288100
  • 10610713
  • 17003236
• RefSeq identity
  • NM_005259
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000132663
• Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_200

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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