Ingenol
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Catalog number2527-5
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PricePlease ask
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Size5 mg
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Alternative_name(1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
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DescriptionIngenol is a diterpenoid related to phorbol that acts as a weak protein kinase C (PKC) activator that displays a Ki value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.
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CAS Number30220-46-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC20H28O5
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Molecular Weight348.44
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO or EtOH
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HandlingProtect from air and light
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Tag LineA protein kinase C (PKC) activator
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life24 months
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MDL NumberMFCD00056380
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PubChem CID442042
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SMILESCC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO
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InChiInChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13,3)4)12(17(19)24)6-11(8-21)16(23)20(19,25)15(9)22/h6-7,10,12-16,21-23,25H,5,8H2,1-4H3/t10-,12+,13-,14+,15+,16-,19+,20-/m1/s1
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InChi KeyEBVPUXQAPLADL-POYOOMFHSA-N
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MSDS AvailableYes
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Gene target
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Short nameIngenol
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Alternative nameIngenol
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