Ingenol

  • Catalog number
    2527-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    (1aR,​2S,​5R,​5aR,​6S,​8aS,​9R,​10aR)-​1a,​2,​5,​5a,​6,​9,​10,​10a-​octahydro-​5,​5a,​6-​trihydroxy-​4-​(hydroxymethyl)-​1,​1,​7,​9-​tetramethyl-​1H-​2,​8a-​methanocyclopenta[a]cyclopropa[e]cyclodecen-​11-​one
  • Description
    Ingenol is a diterpenoid related to phorbol that acts as a weak protein kinase C (PKC) activator that displays a Ki value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.
  • CAS Number
    30220-46-3
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C20H28O5
  • Molecular Weight
    348.44
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO or EtOH
  • Handling
    Protect from air and light
  • Tag Line
    A protein kinase C (PKC) activator
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD00056380
  • PubChem CID
    442042
  • SMILES
    CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO
  • InChi
    InChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13,3)4)12(17(19)24)6-11(8-21)16(23)20(19,25)15(9)22/h6-7,10,12-16,21-23,25H,5,8H2,1-4H3/t10-,12+,13-,14+,15+,16-,19+,20-/m1/s1
  • InChi Key
    EBVPUXQAPLADL-POYOOMFHSA-N
  • MSDS Available
    Yes
  • Gene target
    Ingenol  
  • Short name
    Ingenol
  • Alternative name
    Ingenol
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