BRL-50481, PDE7 inhibitor
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Catalog number
SIH-374-50MG
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Price
Please ask
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Size
50 mg
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Stock availabilitIn Stock
In Stock
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CAS number
433695-36-4
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Description
PDE7 inhibitor
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Molecular weight
244,26 g/mol
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Primary research fields
Neuroscience
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Other name
N,N,2-Trimethyl-5-nitro-benzenesulfonamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C9H12N2O4S
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Origin
Synthetic
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Purity pourcentage
>98% (TLC); NMR (Conforms)
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Soluble in
May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml)
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Physical appearance
Cream solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
2921148
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Scientific context
BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor. In the presence of BRL-50481 the activity of hrPDE7A1 was inhibited against the phosphodiesterase (PDE3) and (PDE4) (1). Studies have suggested a potential role of BRL-50481 in the treatment of osteoporosis (2).
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Bibliography
1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89. 2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.
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Release date
4-Apr-2013
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of BRL-50481 (SIH-374), a PDE7 inhibitor. CAS #: 433695-36-4. Molecular Formula: C9H12N2O4S. Molecular Weight: 244.26 g/mol. Chemical structure of BRL-50481, a PDE7 inhibitor (SIH-374). CAS # 433695-36-4. Molecular Formula: C9H12N2O4S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
BRD1
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Short name
BRL-50481, PDE7 inhibitor
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Alternative name
BRL-50481, PDE7 suppressor
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Gene info
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Identity
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Gene
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Long gene name
bromodomain containing 1
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Synonyms gene name
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1999-10-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PWWP domain containing
- Bromodomain containing
- PHD finger proteins
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VEGA ID
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