BRL-50481, PDE7 inhibitor

  • Catalog number
    SIH-374-50MG
  • Price
    Please ask
  • Size
    50 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    433695-36-4
  • Description
    PDE7 inhibitor
  • Molecular weight
    244,26 g/mol
  • Primary research fields
    Neuroscience
  • Other name
    N,N,2-Trimethyl-5-nitro-benzenesulfonamide
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C9H12N2O4S
  • Origin
    Synthetic
  • Purity pourcentage
    >98% (TLC); NMR (Conforms)
  • Soluble in
    May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml)
  • Physical appearance
    Cream solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
  • PubChem number
    2921148
  • Scientific context
    BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor. In the presence of BRL-50481 the activity of hrPDE7A1 was inhibited against the phosphodiesterase (PDE3) and (PDE4) (1). Studies have suggested a potential role of BRL-50481 in the treatment of osteoporosis (2).
  • Bibliography
    1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89. 2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.
  • Release date
    4-Apr-2013
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of BRL-50481 (SIH-374), a PDE7 inhibitor. CAS #: 433695-36-4. Molecular Formula: C9H12N2O4S. Molecular Weight: 244.26 g/mol. Chemical structure of BRL-50481, a PDE7 inhibitor (SIH-374). CAS # 433695-36-4. Molecular Formula: C9H12N2O4S.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.05
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    BRD1
  • Short name
    BRL-50481, PDE7 inhibitor
  • Alternative name
    BRL-50481, PDE7 suppressor
Gene info
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