ATM Kinase Inhibitor, KU-55933
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Catalog number1685-5
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PricePlease ask
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Size5 mg
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Alternative_name2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
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DescriptionA potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
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CAS Number587871-26-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₁H₁₇NO₃S₂
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Molecular Weight395.49
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Cell PermeableYes
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Purity≥97% by HPLC
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SolubilitiesDMSO (100 mM) and Ethanol (50 mM)
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HandlingProtect from air and light
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Tag LineAn ATM kinase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD08276985
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PubChem CID5278396
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SMILESC1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
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InChiInChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
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InChi KeyXRKYMMUGXMWDAO-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolARMC9, ATM
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Short nameATM Kinase Inhibitor, KU-55933
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Alternative nameataxia telangiectasia mutated phosphorylation catalyst suppressor, KU-55933
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Alternative to gene targetataxia telangiectasia mutated, AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-70193 and ENSG00000149311 and 472, transferase activity, nuclei, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824
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Gene info
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Identity
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Gene
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Long gene namearmadillo repeat containing 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-10-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo repeat containing
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameATM serine/threonine kinase
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Synonyms gene
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Synonyms gene name
- ataxia telangiectasia mutated (includes complementation groups A, C and D)
- ataxia telangiectasia mutated
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-07-07
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Entrez gene record
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases