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anti-COCO/DAND5 Antibody

  • Catalog number
    3626-100
  • Product name
    anti-COCO/DAND5 Antibody
  • Size
    COCO/DAND5 Antibody
  • Price
    338EUR
  • Supplier
    biovision antibodies-kits-proteins
  • Antibody host:
    Rabbit
  • This antibody reacts with:
    Human, mouse, rat
  • Purification method:
    Affinity purified
  • Immunogene sequence:
    Synthetic peptide at C-terminal (BV-MM26)
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    Western blot
  • Target of this antibody:
    COCO/DAND5
  • Formulation of this antibody:
    100 µg (0.5 mg/ml) of antibody in PBS containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2.
  • Alternative names of antibody target:
    DANTE, CKTSF1B3, DAN domain family member 5, Cerberus-like 2 protein
  • Recommended usage:
    Western blot: 1:200
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • Background information:
    COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and Cerberus (DAND4). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF­β superfamily ligands such as BMPs that play important roles in tissue morphogenesis and developmental processes. COCO has eight Cys residues in the cysteine knot which places it in the CAN (or eight­membered ring) subfamily of BMP antagonists along with the other DAN family proteins. In Xenopus embryos, COCO is expressed by pluripotent ectodermal cells. Expression is abruptly downregulated prior to gastrulation, and the loss of ectodermal cell pluripotency is coincident with COCO downregulation. COCO is required for Xenopus left­right axis formation. It functions predominantly on the right side of the embryo, although it is equally expressed on both left and right sides. COCO binds and inhibits activin, BMP­4, GDF3/derrière, Wnt8, and Xnr1. In mouse, COCO expression is elevated on the right side of Henson’s node at the early somite stage, in contrast to the left side expression of Nodal.
  • Concentration of antibody:
    0.5 mg/ml
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Gene target
  • Short name
    anti-COCO/DAND5 Antibody
  • Technique
    Antibody, antibody to, antibodies against human proteins, antibodies for
  • Alternative name
    antibody to-COCO/DAN domain family, member 5 (Antibody to)
  • Alternative technique
    antibodies
  • Alternative to gene target
    DAN domain family, member 5, DAND5 and IDBG-31601 and ENSG00000179284 and 199699, this GO :0003140 and determination of left/right asymmetry in lateral mesoderm and biological process this GO :0003281 and ventricular septum development and biological process this GO :0003283 and atrial septum development and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0007368 and determination of left/right symmetry and biological process this GO :0016015 and morphogen activity and molecular function this GO :0017015 and regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0038101 and sequestering of nodal from receptor via nodal binding and biological process this GO :0061371 and determination of heart left/right asymmetry and biological process this GO :1900108 and negative regulation of nodal signaling pathway and biological process, morphogen activity, this GO :0005515: protein binding and also this GO :0016015: morphogen activity, this GO :0005515: protein binding, this GO :0016015: morphogen activity, Extracellular, Dand5 and IDBG-174811 and ENSMUSG00000053226 and 23863
1. Gene info
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